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Publications 

2022

Sartoretti T, Ganley RP, Ni R, Freund P, Zeilhofer HU, Klohs J. Structural MRI Reveals Cervical Spinal Cord Atrophy in the P301L Mouse Model of Tauopathy: Gender and Transgene-Dosing Effects. Front Aging Neurosci. 2022 May 2;14:825996. doi: 10.3389/fnagi.2022.825996. PMID: 35585865; PMCID: PMC9108240.​  PubMed

Freund P, Papinutto N, Bischof A, Azzarito M, Kirkish G, Ashburner J, Thompson A, Hauser SL, Henry RG. Simultaneous assessment of regional distributions of atrophy across the neuraxis in MS patients. Neuroimage Clin. 2022;34:102985. doi: 10.1016/j.nicl.2022.102985. Epub 2022 Mar 8. PMID: 35316667; PMCID: PMC8938332.   PubMed

Martin AR, Tetreault L, Nouri A, Curt A, Freund P, Rahimi-Movaghar V, Wilson JR, Fehlings MG, Kwon BK, Harrop JS, Davies BM, Kotter MRN, Guest JD, Aarabi B, Kurpad SN. Imaging and Electrophysiology for Degenerative Cervical Myelopathy [AO Spine RECODE-DCM Research Priority Number 9]. Global Spine J. 2022 Feb;12(1_suppl):130S-146S. doi: 10.1177/21925682211057484. Epub 2021 Nov 19. PMID: 34797993; PMCID: PMC8859711.    PubMed

Davies BM, Mowforth O, Gharooni AA, Tetreault L, Nouri A, Dhillon RS, Bednarik J, Martin AR, Young A, Takahashi H, Boerger TF, Newcombe VF, Zipser CM, Freund P, Koljonen PA, Rodrigues-Pinto R, Rahimi-Movaghar V, Wilson JR, Kurpad SN, Fehlings MG, Kwon BK, Harrop JS, Guest JD, Curt A, Kotter MRN. A New Framework for Investigating the Biological Basis of Degenerative Cervical Myelopathy [AO Spine RECODE-DCM Research Priority Number 5]: Mechanical Stress, Vulnerability and Time. Global Spine J. 2022 Feb;12(1_suppl):78S-96S. doi: 10.1177/21925682211057546. PMID: 35174728; PMCID: PMC8859710.    PubMed

David G, Vallotton K, Hupp M, Curt A, Freund P, Seif M. Extent of Cord Pathology in the Lumbosacral Enlargement in Non-Traumatic versus Traumatic Spinal Cord Injury. J Neurotrauma. 2022 May;39(9-10):639-650. doi: 10.1089/neu.2021.0389. Epub 2022 Feb 8. PMID: 35018824.    PubMed

2021

Pfyffer D, Freund P. Spinal cord pathology revealed by MRI in traumatic spinal cord injury. Curr Opin Neurol. 2021 Dec 1;34(6):789-795. doi: 10.1097/WCO.0000000000000998. PMID: 34619692.   PubMed

Vallotton K, David G, Hupp M, Pfender N, Cohen-Adad J, Fehlings MG, Samson RS, Wheeler-Kingshott CAMG, Curt A, Freund P, Seif M. Tracking White and Gray Matter Degeneration along the Spinal Cord Axis in Degenerative Cervical Myelopathy. J Neurotrauma. 2021 Nov 1;38(21):2978-2987. doi: 10.1089/neu.2021.0148. Epub 2021 Aug 3. PMID: 34238034.   PubMed

Schading S, Pohl H, Gantenbein A, Luechinger R, Sandor P, Riederer F, Freund P, Michels L. Tracking tDCS induced grey matter changes in episodic migraine: a randomized controlled trial. J Headache Pain. 2021 Nov 20;22(1):139. doi: 10.1186/s10194-021-01347-y. PMID: 34800989; PMCID: PMC8605508.   PubMed

Michels L, Stämpfli P, Aldusary N, Piccirelli M, Freund P, Weber KP, Fierz FC, Kollias S, Traber G. Widespread White Matter Alterations in Patients With Visual Snow Syndrome. Front Neurol. 2021 Sep 21;12:723805. doi: 10.3389/fneur.2021.723805. PMID: 34621237; PMCID: PMC8490630.   PubMed

Cohen-Adad J, Alonso-Ortiz E, Abramovic M, Arneitz C, Atcheson N, Barlow L, Barry RL, Barth M, Battiston M, Büchel C, Budde M, Callot V, Combes AJE, De Leener B, Descoteaux M, de Sousa PL, Dostál M, Doyon J, Dvorak A, Eippert F, Epperson KR, Epperson KS, Freund P, Finsterbusch J, Foias A, Fratini M, Fukunaga I, Wheeler-Kingshott CAMG, Germani G, Gilbert G, Giove F, Gros C, Grussu F, Hagiwara A, Henry PG, Horák T, Hori M, Joers J, Kamiya K, Karbasforoushan H, Keřkovský M, Khatibi A, Kim JW, Kinany N, Kitzler H, Kolind S, Kong Y, Kudlička P, Kuntke P, Kurniawan ND, Kusmia S, Labounek R, Laganà MM, Laule C, Law CS, Lenglet C, Leutritz T, Liu Y, Llufriu S, Mackey S, Martinez-Heras E, Mattera L, Nestrasil I, O'Grady KP, Papinutto N, Papp D, Pareto D, Parrish TB, Pichiecchio A, Prados F, Rovira À, Ruitenberg MJ, Samson RS, Savini G, Seif M, Seifert AC, Smith AK, Smith SA, Smith ZA, Solana E, Suzuki Y, Tackley G, Tinnermann A, Valošek J, Van De Ville D, Yiannakas MC, Weber KA 2nd, Weiskopf N, Wise RG, Wyss PO, Xu J. Generic acquisition protocol for quantitative MRI of the spinal cord. Nat Protoc. 2021 Oct;16(10):4611-4632. doi: 10.1038/s41596-021-00588-0. Epub 2021 Aug 16. PMID: 34400839; PMCID: PMC8811488.   PubMed

Scheuren PS, David G, Kipling Kramer JL, Jutzeler CR, Hupp M, Freund P, Curt A, Hubli M, Rosner J. Combined Neurophysiologic and Neuroimaging Approach to Reveal the Structure-Function Paradox in Cervical Myelopathy. Neurology. 2021 Aug 11:10.1212/WNL.0000000000012643. doi: 10.1212/WNL.0000000000012643. Epub ahead of print. PMID: 34380751.    PubMed

Cohen-Adad J, Alonso-Ortiz E, Abramovic M, Arneitz C, Atcheson N, Barlow L, Barry RL, Barth M, Battiston M, Büchel C, Budde M, Callot V, Combes AJE, De Leener B, Descoteaux M, de Sousa PL, Dostál M, Doyon J, Dvorak A, Eippert F, Epperson KR, Epperson KS, Freund P, Finsterbusch J, Foias A, Fratini M, Fukunaga I, Gandini Wheeler-Kingshott CAM, Germani G, Gilbert G, Giove F, Gros C, Grussu F, Hagiwara A, Henry PG, Horák T, Hori M, Joers J, Kamiya K, Karbasforoushan H, Keřkovský M, Khatibi A, Kim JW, Kinany N, Kitzler HH, Kolind S, Kong Y, Kudlička P, Kuntke P, Kurniawan ND, Kusmia S, Labounek R, Laganà MM, Laule C, Law CS, Lenglet C, Leutritz T, Liu Y, Llufriu S, Mackey S, Martinez-Heras E, Mattera L, Nestrasil I, O'Grady KP, Papinutto N, Papp D, Pareto D, Parrish TB, Pichiecchio A, Prados F, Rovira À, Ruitenberg MJ, Samson RS, Savini G, Seif M, Seifert AC, Smith AK, Smith SA, Smith ZA, Solana E, Suzuki Y, Tackley G, Tinnermann A, Valošek J, Van De Ville D, Yiannakas MC, Weber Ii KA, Weiskopf N, Wise RG, Wyss PO, Xu J. Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers. Sci Data. 2021 Aug 16;8(1):219. doi: 10.1038/s41597-021-00941-8. Erratum in: Sci Data. 2021 Sep 10;8(1):242. Erratum in: Sci Data. 2021 Sep 23;8(1):251. PMID: 34400655; PMCID: PMC8368310.    PubMed

David G, Pfyffer D, Vallotton K, Pfender N, Thompson A, Weiskopf N, Mohammadi S, Curt A, Freund P. Longitudinal changes of spinal cord grey and white matter following spinal cord injury. J Neurol Neurosurg Psychiatry. 2021 Aug 2:jnnp-2021-326337. doi: 10.1136/jnnp-2021-326337. Epub ahead of print. PMID: 34341143.​    PubMed

Schading S, Emmenegger TM, Freund P. Improving Diagnostic Workup Following Traumatic Spinal Cord Injury: Advances in Biomarkers. Curr Neurol Neurosci Rep. 2021 Jul 16;21(9):49. doi: 10.1007/s11910-021-01134-x. PMID: 34268621; PMCID: PMC8282571.​     PubMed

Emmenegger TM, David G, Ashtarayeh M, Fritz FJ, Ellerbrock I, Helms G, Balteau E, Freund P, Mohammadi S. The Influence of Radio-Frequency Transmit Field Inhomogeneities on the Accuracy of G-ratio Weighted Imaging. Front Neurosci. 2021 Jul 5;15:674719. doi: 10.3389/fnins.2021.674719. PMID: 34290579; PMCID: PMC8287210.    PubMed

Kyathanahally SP, Azzarito M, Rosner J, Calhoun VD, Blaiotta C, Ashburner J, Weiskopf N, Wiech K, Friston K, Ziegler G, Freund P. Microstructural plasticity in nociceptive pathways after spinal cord injury. J Neurol Neurosurg Psychiatry. 2021 May 26:jnnp-2020-325580. doi: 10.1136/jnnp-2020-325580. Epub ahead of print. PMID: 34039630.​     PubMed

Fischer T, Stern C, Freund P, Schubert M, Sutter R. Wallerian degeneration in cervical spinal cord tracts is commonly seen in routine T2-weighted MRI after traumatic spinal cord injury and is associated with impairment in a retrospective study. Eur Radiol. 2021 May;31(5):2923-2932. doi: 10.1007/s00330-020-07388-2. Epub 2020 Oct 30. PMID: 33125565; PMCID: PMC8043949.     PubMed

Michela Azzarito, Gabriel Ziegler, Eveline Huber, Patrick Grabher, Martina F. Callaghan,  Alan Thompson,  Karl Friston, Nikolaus Weiskopf, Tim Killeen, Patrick Freund. Coherent waves of myelin plasticity during motor-skill learning. bioRxiv 2021.04.13.439402; doi: https://doi.org/10.1101/2021.04.13.439402

bioRxiv

Walter M, Leitner L, Betschart C, Engeler DS, Freund P, Kessler TM, Kollias S, Liechti MD, Scheiner DA, Michels L, Mehnert U. Considering non-bladder aetiologies of overactive bladder: a functional neuroimaging study. BJU Int. 2021 Feb 5. doi: 10.1111/bju.15354.       PubMed

Hupp M, Pfender N, Vallotton K, Rosner J, Friedl S, Zipser CM, Sutter R, Klarhöfer M, Spirig JM, Betz M, Schubert M, Freund P, Farshad M, Curt A. The Restless Spinal Cord in Degenerative Cervical Myelopathy.  AJNR Am J Neuroradiol. 2021 Mar;42(3):597-609. doi: 10.3174/ajnr.A6958. Epub 2021 Feb 4. PMID: 33541903    PubMed

Kikkert S, Pfyffer D, Verling M, Freund P, Wenderoth N. Finger somatotopy is preserved after tetraplegia but deteriorates over time. Elife. 2021 Oct 19;10:e67713. doi: 10.7554/eLife.67713. PMID: 34665133; PMCID: PMC8575460.     PubMed

Pfyffer D, Vallotton K, Curt A, Freund P. Predictive Value of Midsagittal Tissue Bridges on Functional Recovery After Spinal Cord Injury. Neurorehabil Neural Repair. 2021;35(1):33-43. doi:10.1177/1545968320971787.    PubMed

Azzarito M, Kyathanahally SP, Balbastre Y, Seif M, Blaiotta C, Callaghan MF, Ashburner J, Freund P. Simultaneous voxel-wise analysis of brain and spinal cord morphometry and microstructure within the SPM framework. Hum Brain Mapp. 2021 Jan;42(1):220-232. doi: 10.1002/hbm.25218.    PubMed

 
 

2020

Aldusary N, Traber GL, Freund P, Fierz FC, Weber KP, Baeshen A, Alghamdi J, Saliju B, Pazahr S, Mazloum R, Alshehri F, Landau K, Kollias S, Piccirelli M, Michels L. Abnormal Connectivity and Brain Structure in Patients With Visual Snow. Front Hum Neurosci. 2020 Nov 19;14:582031. doi: 10.3389/fnhum.2020.582031. PMID: 33328934; PMCID: PMC7710971.​    PubMed

Pfyffer D, Vallotton K, Curt A, Freund P. Tissue bridges predict neuropathic pain emergence after spinal cord injury. J Neurol Neurosurg Psychiatry. 2020;91(10):1111-1117. doi:10.1136/jnnp-2020-323150.      PubMed

Leutritz T, Seif M, Helms G, Samson RS, Curt A, Freund P, Weiskopf N. Multiparameter mapping of relaxation (R1, R2*), proton density and magnetization transfer saturation at 3 T: A multicenter dual-vendor reproducibility and repeatability study. Hum Brain Mapp. 2020 Oct 15;41(15):4232-4247. doi: 10.1002/hbm.25122.    PubMed

Huber E, Patel R, Hupp M, Weiskopf N, Chakravarty MM, Freund P. Extrapyramidal plasticity predicts recovery after spinal cord injury. Sci Rep. 2020 Aug 24;10(1):14102. doi: 10.1038/s41598-020-70805-5. 

PubMed

Pfyffer D, Wyss PO, Huber E, Curt A, Henning A, Freund P. Metabolites of neuroinflammation relate to neuropathic pain after spinal cord injury. Neurology. 2020;95(7):e805-e814. doi:10.1212/WNL.0000000000010003.     PubMed

Birkhäuser V, Liechti MD, Anderson CE, Bachmann LM, Baumann S, Baumberger M, Birder LA, Botter SM, Büeler S, Cruz CD, David G, Freund P, Friedl S, Gross O, Hund-Georgiadis M, Husmann K, Jordan X, Koschorke M, Leitner L, Luca E, Mehnert U, Möhr S, Mohammadzada F, Monastyrskaya K, Pfender N, Pohl D, Sadri H, Sartori AM, Schubert M, Sprengel K, Stalder SA, Stoyanov J, Stress C, Tatu A, Tawadros C, van der Lely S, Wöllner J, Zubler V, Curt A, Pannek J, Brinkhof MWG, Kessler TM. TASCI-transcutaneous tibial nerve stimulation in patients with acute spinal cord injury to prevent neurogenic detrusor overactivity: protocol for a nationwide, randomised, sham-controlled, double-blind clinical trial. BMJ Open. 2020 Aug 13;10(8):e039164. doi: 10.1136/bmjopen-2020-039164.    PubMed

Curt A, Hsieh J, Schubert M, Hupp M, Friedl S, Freund P, Huber E, Pfyffer D, Sutter R, Jutzeler C, Wüthrich RP, Min K, Casha S, Fehlings MG, Guzman R. The Damaged Spinal Cord Is a Suitable Target for Stem Cell Transplantation. Neurorehabil Neural Repair. 2020 Aug;34(8):758-768. doi: 10.1177/1545968320935815.  PubMed

Seif M, David G, Huber E, Vallotton K, Curt A, Freund P. Cervical Cord Neurodegeneration in Traumatic and Non-Traumatic Spinal Cord Injury. J Neurotrauma. 2020 Mar 15;37(6):860-867. doi: 10.1089/neu.2019.6694.  PubMed

Azzarito M, Seif M, Kyathanahally S, Curt A, Freund P. Tracking the neurodegenerative gradient after spinal cord injury. Neuroimage Clin. 2020;26:102221. doi: 10.1016/j.nicl.2020.102221.    PubMed

2019

Freund P, Seif M, Weiskopf N, Friston K, Fehlings MG, Thompson AJ, Curt A. MRI in traumatic spinal cord injury: from clinical assessment to neuroimaging biomarkers. Lancet Neurol. 2019 Dec;18(12):1123-1135. doi: 10.1016/S1474-4422(19)30138-3. ​   PubMed

David G, Mohammadi S, Martin AR, et al. Traumatic and nontraumatic spinal cord injury: pathological insights from neuroimaging. Nat Rev Neurol. 2019;15:718–731.    PubMed

Pfyffer D, Huber E, Sutter R, Curt A, Freund P. Tissue bridges predict recovery after traumatic and ischemic thoracic spinal cord injury. Neurology. 2019;93(16):e1550-e1560. doi:10.1212/WNL.0000000000008318.

PubMed

Seif M, Gandini Wheeler-Kingshott CA, Cohen-Adad J, Flanders AE, Freund P. Guidelines for the conduct of clinical trials in spinal cord injury: Neuroimaging biomarkers. Spinal Cord. 2019 Sep;57(9):717-728. doi: 10.1038/s41393-019-0309-x.    PubMed

Vallotton K, Huber E, Sutter R, Curt A, Hupp M, Freund P. Width and neurophysiologic properties of tissue bridges predict recovery after cervical injury. Neurology. 2019 Jun 11;92(24):e2793-e2802. doi: 10.1212/WNL.0000000000007642.    PubMed

Walter M, Leitner L, Michels L, Liechti MD, Freund P, Kessler TM, Kollias S, Mehnert U. Reliability of supraspinal correlates to lower urinary tract stimulation in healthy participants - A fMRI study. Neuroimage. 2019 May 1;191:481-492. doi: 10.1016/j.neuroimage.2019.02.031. Epub 2019 Feb 15. PMID: 30776530.    PubMed

Wyss PO, Huber E, Curt A, Kollias S, Freund P, Henning A. MR Spectroscopy of the Cervical Spinal Cord in Chronic Spinal Cord Injury. Radiology. 2019 Apr;291(1):131-138. doi: 10.1148/radiol.2018181037.    PubMed

David G, Seif M, Huber E, et al. In vivo evidence of remote neural degeneration in the lumbar enlargement after cervical injury. Neurology. 2019;92.     PubMed

2018

Seif M, Ziegler G, Freund P. Progressive Ventricles Enlargement and Cerebrospinal Fluid Volume Increases as a Marker of Neurodegeneration in Patients with Spinal Cord Injury: A Longitudinal Magnetic Resonance Imaging Study. J Neurotrauma. 2018 Dec 15;35(24):2941-2946. doi: 10.1089/neu.2017.5522.    PubMed

Seif M, Curt A, Thompson AJ, Grabher P, Weiskopf N, Freund P. Quantitative MRI of rostral spinal cord and brain regions is predictive of functional recovery in acute spinal cord injury. Neuroimage Clin. 2018 Aug 19;20:556-563. doi: 10.1016/j.nicl.2018.08.026.​    PubMed

Wolf K, Hupp M, Friedl S, Sutter R, Klarhöfer M, Grabher P, Freund P, Curt A. In cervical spondylotic myelopathy spinal cord motion is focally increased at the level of stenosis: a controlled cross-sectional study. Spinal Cord. 2018 Aug;56(8):769-776. doi: 10.1038/s41393-018-0075-1. ​    PubMed

Huber E, David G, Thompson AJ, Weiskopf N, Mohammadi S, Freund P. Dorsal and ventral horn atrophy is associated with clinical outcome after spinal cord injury. Neurology. 2018 Apr 24;90(17):e1510-e1522. doi: 10.1212/WNL.0000000000005361.     PubMed

Ziegler G, Grabher P, Thompson A, Altmann D, Hupp M, Ashburner J, Friston K, Weiskopf N, Curt A, Freund P. Progressive neurodegeneration following spinal cord injury: Implications for clinical trials. Neurology. 2018 Apr 3;90(14):e1257-e1266. doi: 10.1212/WNL.0000000000005258.    PubMed

Blaiotta C, Freund P, Cardoso MJ, Ashburner J. Generative diffeomorphic modelling of large MRI data sets for probabilistic template construction. Neuroimage. 2018 Feb 1;166:117-134. doi: 10.1016/j.neuroimage.2017.10.060. Epub 2017 Oct 31. PMID: 29100938; PMCID: PMC5770340.   PubMed

2017

2016

David G, Freund P, Mohammadi S. The efficiency of retrospective artifact correction methods in improving the statistical power of between-group differences in spinal cord DTI. Neuroimage. 2017 Sep;158:296-307. doi: 10.1016/j.neuroimage.2017.06.051.    PubMed

Grabher P, Mohammadi S, David G, Freund P. Neurodegeneration in the Spinal Ventral Horn Prior to Motor Impairment in Cervical Spondylotic Myelopathy. J Neurotrauma. 2017 Aug 1;34(15):2329-2334. doi: 10.1089/neu.2017.4980.    PubMed

Grabher P, Blaiotta C, Ashburner J, Freund P. Relationship between brainstem neurodegeneration and clinical impairment in traumatic spinal cord injury. Neuroimage Clin. 2017 Jun 1;15:494-501. doi: 10.1016/j.nicl.2017.05.026.    PubMed

Huber E, Lachappelle P, Sutter R, Curt A, Freund P. Are midsagittal tissue bridges predictive of outcome after cervical spinal cord injury? Ann Neurol. 2017 May;81(5):740-748. doi: 10.1002/ana.24932.    PubMed

Prados F, Ashburner J, Blaiotta C, Brosch T, Carballido-Gamio J, Cardoso MJ, Conrad BN, Datta E, Dávid G, Leener B, Dupont SM, Freund P, Wheeler-Kingshott CAMG, Grussu F, Henry R, Landman BA, Ljungberg E, Lyttle B, Ourselin S, Papinutto N, Saporito S, Schlaeger R, Smith SA, Summers P, Tam R, Yiannakas MC, Zhu A, Cohen-Adad J. Spinal cord grey matter segmentation challenge. Neuroimage. 2017 May 15;152:312-329. doi: 10.1016/j.neuroimage.2017.03.010.   PubMed

Freund P, Friston K, Thompson AJ, Stephan KE, Ashburner J, Bach DR, Nagy Z, Helms G, Draganski B, Mohammadi S, Schwab ME, Curt A, Weiskopf N. Embodied neurology: an integrative framework for neurological disorders. Brain. 2016 Jun;139(Pt 6):1855-61. doi: 10.1093/brain/aww076.    PubMed

Grabher P, Mohammadi S, Trachsler A, Friedl S, David G, Sutter R, Weiskopf N, Thompson AJ, Curt A, Freund P. Voxel-based analysis of grey and white matter degeneration in cervical spondylotic myelopathy. Sci Rep. 2016 Apr 20;6:24636. doi: 10.1038/srep24636.     PubMed

Ionta S, Villiger M, Jutzeler CR, Freund P, Curt A, Gassert R. Spinal cord injury affects the interplay between visual and sensorimotor representations of the body. Sci Rep. 2016 Feb 4;6:20144. doi: 10.1038/srep20144. Erratum in: Sci Rep. 2016;7:24693. PMID: 26842303; PMCID: PMC4740737.    PubMed

Leh SE, Kälin AM, Schroeder C, Park MT, Chakravarty MM, Freund P, Gietl AF, Riese F, Kollias S, Hock C, Michels L. Volumetric and shape analysis of the thalamus and striatum in amnestic mild cognitive impairment. J Alzheimers Dis. 2016;49(1):237-49. doi: 10.3233/JAD-150080. PMID: 26444755.   PubMed

Jutzeler CR, Huber E, Callaghan MF, Luechinger R, Curt A, Kramer JL, Freund P. Association of pain and CNS structural changes after spinal cord injury. Sci Rep. 2016 Jan 6;6:18534. doi: 10.1038/srep18534.    PubMed

2015

Jutzeler CR, Freund P, Huber E, Curt A, Kramer JLK. Neuropathic Pain and Functional Reorganization in the Primary Sensorimotor Cortex After Spinal Cord Injury. J Pain. 2015 Dec;16(12):1256-1267. doi: 10.1016/j.jpain.2015.08.008.​    PubMed

Grabher P, Callaghan MF, Ashburner J, Weiskopf N, Thompson AJ, Curt A, Freund P. Tracking sensory system atrophy and outcome prediction in spinal cord injury. Ann Neurol. 2015 Nov;78(5):751-61. doi: 10.1002/ana.24508. ​    PubMed

Huber E, Curt A, Freund P. Tracking trauma-induced structural and functional changes above the level of spinal cord injury. Curr Opin Neurol. 2015 Aug;28(4):365-72. doi: 10.1097/WCO.0000000000000224.  PubMed

Villiger M, Grabher P, Hepp-Reymond MC, Kiper D, Curt A, Bolliger M, Hotz-Boendermaker S, Kollias S, Eng K, Freund P. Relationship between structural brainstem and brain plasticity and lower-limb training in spinal cord injury: a longitudinal pilot study. Front Hum Neurosci. 2015 May 6;9:254. doi: 10.3389/fnhum.2015.00254.    PubMed

2014

Leitner L, Walter M, Freund P, Mehnert U, Michels L, Kollias S, Kessler TM. Protocol for a prospective magnetic resonance imaging study on supraspinal lower urinary tract control in healthy subjects and spinal cord injury patients undergoing intradetrusor onabotulinumtoxinA injections for treating neurogenic detrusor overactivity. BMC Urol. 2014 Aug 18;14:68. doi: 10.1186/1471-2490-14-68. PMID: 25132340; PMCID: PMC4144688.   PubMed

Haefeli J, Freund P, Kramer JL, Blum J, Luechinger R, Curt A. Differences in cortical coding of heat evoked pain beyond the perceived intensity: an fMRI and EEG study. Hum Brain Mapp. 2014 Apr;35(4):1379-89. doi: 10.1002/hbm.22260. Epub 2013 Mar 1. PMID: 23450833; PMCID: PMC6869572.   PubMed

Callaghan MF, Freund P, Draganski B, Anderson E, Cappelletti M, Chowdhury R, Diedrichsen J, Fitzgerald TH, Smittenaar P, Helms G, Lutti A, Weiskopf N. Widespread age-related differences in the human brain microstructure revealed by quantitative magnetic resonance imaging. Neurobiol Aging. 2014 Aug;35(8):1862-72. doi: 10.1016/j.neurobiolaging.2014.02.008. Epub 2014 Feb 15. PMID: 24656835; PMCID: PMC4024196.   PubMed

2013

Freund P, Weiskopf N, Ashburner J, Wolf K, Sutter R, Altmann DR, Friston K, Thompson A, Curt A. MRI investigation of the sensorimotor cortex and the corticospinal tract after acute spinal cord injury: a prospective longitudinal study. Lancet Neurol. 2013 Sep;12(9):873-881. doi: 10.1016/S1474-4422(13)70146-7.​

PubMed

Mohammadi S, Freund P, Feiweier T, Curt A, Weiskopf N. The impact of post-processing on spinal cord diffusion tensor imaging. Neuroimage. 2013 Apr 15;70:377-85. doi: 10.1016/j.neuroimage.2012.12.058. Epub 2013 Jan 5. PMID: 23298752; PMCID: PMC3605597.   PubMed

Freund P, Curt A, Friston K, Thompson A. Tracking changes following spinal cord injury: insights from neuroimaging. Neuroscientist. 2013 Apr;19(2):116-28. doi: 10.1177/1073858412449192.     PubMed

2012

Freund P, Schneider T, Nagy Z, Hutton C, Weiskopf N, Friston K, Wheeler-Kingshott CA, Thompson AJ. Degeneration of the injured cervical cord is associated with remote changes in corticospinal tract integrity and upper limb impairment. PLoS One. 2012;7(12):e51729. doi: 10.1371/journal.pone.0051729. Epub 2012 Dec 12. PMID: 23251612; PMCID: PMC3520920.  PubMed

Freund P, Wheeler-Kingshott CA, Nagy Z, Gorgoraptis N, Weiskopf N, Friston K, Thompson AJ, Hutton C. Axonal integrity predicts cortical reorganisation following cervical injury. J Neurol Neurosurg Psychiatry. 2012 Jun;83(6):629-37. doi: 10.1136/jnnp-2011-301875. Epub 2012 Apr 6. PMID: 22492214; PMCID: PMC3348614.   PubMed

2011

Freund P, Rothwell J, Craggs M, Thompson AJ, Bestmann S. Corticomotor representation to a human forearm muscle changes following cervical spinal cord injury. Eur J Neurosci. 2011 Dec;34(11):1839-46. doi: 10.1111/j.1460-9568.2011.07895.x. Epub 2011 Nov 14. PMID: 22082003.   PubMed

Freund P, Weiskopf N, Ward NS, Hutton C, Gall A, Ciccarelli O, Craggs M, Friston K, Thompson AJ. Disability, atrophy and cortical reorganization following spinal cord injury. Brain. 2011 Jun;134(Pt 6):1610-22. doi: 10.1093/brain/awr093. Epub 2011 May 17. PMID: 21586596; PMCID: PMC3102242.   PubMed

2010

Freund PA, Dalton C, Wheeler-Kingshott CA, Glensman J, Bradbury D, Thompson AJ, Weiskopf N. Method for simultaneous voxel-based morphometry of the brain and cervical spinal cord area measurements using 3D-MDEFT. J Magn Reson Imaging. 2010 Nov;32(5):1242-7. doi: 10.1002/jmri.22340. PMID: 21031531; PMCID: PMC3078516.   PubMed

Freund P, Wheeler-Kingshott C, Jackson J, Miller D, Thompson A, Ciccarelli O. Recovery after spinal cord relapse in multiple sclerosis is predicted by radial diffusivity. Mult Scler. 2010 Oct;16(10):1193-202. doi: 10.1177/1352458510376180. Epub 2010 Aug 4. PMID: 20685759; PMCID: PMC2951108.   PubMed

2009

Schmidlin E, Jouffrais C, Freund P, Wannier-Morino P, Beaud ML, Rouiller EM, Wannier T. A case of polymicrogyria in macaque monkey: impact on anatomy and function of the motor system. BMC Neurosci. 2009 Dec 23;10:155. doi: 10.1186/1471-2202-10-155. PMID: 20030837; PMCID: PMC2807873.   PubMed

Freund P, Schmidlin E, Wannier T, Bloch J, Mir A, Schwab ME, Rouiller EM. Anti-Nogo-A antibody treatment promotes recovery of manual dexterity after unilateral cervical lesion in adult primates--re-examination and extension of behavioral data. Eur J Neurosci. 2009 Mar;29(5):983-96. doi: 10.1111/j.1460-9568.2009.06642.x. PMID: 19291225; PMCID: PMC2695186.   PubMed

2008

2007

Beaud ML, Schmidlin E, Wannier T, Freund P, Bloch J, Mir A, Schwab ME, Rouiller EM. Anti-Nogo-A antibody treatment does not prevent cell body shrinkage in the motor cortex in adult monkeys subjected to unilateral cervical cord lesion. BMC Neurosci. 2008 Jan 14;9:5. doi: 10.1186/1471-2202-9-5. PMID: 18194520; PMCID: PMC2242790.   PubMed

Freund P, Wannier T, Schmidlin E, Bloch J, Mir A, Schwab ME, Rouiller EM. Anti-Nogo-A antibody treatment enhances sprouting of corticospinal axons rostral to a unilateral cervical spinal cord lesion in adult macaque monkey. J Comp Neurol. 2007 Jun 1;502(4):644-59. doi: 10.1002/cne.21321. PMID: 17394135.  PubMed

2006

Freund P, Schmidlin E, Wannier T, Bloch J, Mir A, Schwab ME, Rouiller EM. Nogo-A-specific antibody treatment enhances sprouting and functional recovery after cervical lesion in adult primates. Nat Med. 2006 Jul;12(7):790-2. doi: 10.1038/nm1436. Epub 2006 Jul 2. Erratum in: Nat Med. 2006 Oct;12(10):1220. PMID: 16819551.    PubMed