Publications of the group

2021

David G, Pfyffer D, Vallotton K, Pfender N, Thompson A, Weiskopf N, Mohammadi S, Curt A, Freund P. Longitudinal changes of spinal cord grey and white matter following spinal cord injury. J Neurol Neurosurg Psychiatry. 2021 Aug 2:jnnp-2021-326337. doi: 10.1136/jnnp-2021-326337. Epub ahead of print. PMID: 34341143.​    PubMed

Schading S, Emmenegger TM, Freund P. Improving Diagnostic Workup Following Traumatic Spinal Cord Injury: Advances in Biomarkers. Curr Neurol Neurosci Rep. 2021 Jul 16;21(9):49. doi: 10.1007/s11910-021-01134-x. PMID: 34268621; PMCID: PMC8282571.​     PubMed

Emmenegger TM, David G, Ashtarayeh M, Fritz FJ, Ellerbrock I, Helms G, Balteau E, Freund P, Mohammadi S. The Influence of Radio-Frequency Transmit Field Inhomogeneities on the Accuracy of G-ratio Weighted Imaging. Front Neurosci. 2021 Jul 5;15:674719. doi: 10.3389/fnins.2021.674719. PMID: 34290579; PMCID: PMC8287210.    PubMed

Kyathanahally SP, Azzarito M, Rosner J, Calhoun VD, Blaiotta C, Ashburner J, Weiskopf N, Wiech K, Friston K, Ziegler G, Freund P. Microstructural plasticity in nociceptive pathways after spinal cord injury. J Neurol Neurosurg Psychiatry. 2021 May 26:jnnp-2020-325580. doi: 10.1136/jnnp-2020-325580. Epub ahead of print. PMID: 34039630.​     PubMed

Fischer T, Stern C, Freund P, Schubert M, Sutter R. Wallerian degeneration in cervical spinal cord tracts is commonly seen in routine T2-weighted MRI after traumatic spinal cord injury and is associated with impairment in a retrospective study. Eur Radiol. 2021 May;31(5):2923-2932. doi: 10.1007/s00330-020-07388-2. Epub 2020 Oct 30. PMID: 33125565; PMCID: PMC8043949.     PubMed

 

Kevin Vallotton, Gergely David, Markus Hupp, Nikolai Pfender, Julien Cohen-Adad,  Michael Fehlings,  Rebecca S. Samson, Claudia A. M. Gandini Wheeler-Kingshott,  Armin Curt,  Patrick Freund,  Maryam Seif.  Tracking white and grey matter degeneration along the spinal cord axis in degenerative cervical myelopathy. medRxiv 2021.04.18.21255238; doi: https://doi.org/10.1101/2021.04.18.21255238

medRxiv       PubMed

Michela Azzarito, Gabriel Ziegler, Eveline Huber, Patrick Grabher, Martina F. Callaghan,  Alan Thompson,  Karl Friston, Nikolaus Weiskopf, Tim Killeen, Patrick Freund. Coherent waves of myelin plasticity during motor-skill learning. bioRxiv 2021.04.13.439402; doi: https://doi.org/10.1101/2021.04.13.439402

bioRxiv

Walter M, Leitner L, Betschart C, Engeler DS, Freund P, Kessler TM, Kollias S, Liechti MD, Scheiner DA, Michels L, Mehnert U. Considering non-bladder aetiologies of overactive bladder: a functional neuroimaging study. BJU Int. 2021 Feb 5. doi: 10.1111/bju.15354.       PubMed

Hupp M, Pfender N, Vallotton K, Rosner J, Friedl S, Zipser CM, Sutter R, Klarhöfer M, Spirig JM, Betz M, Schubert M, Freund P, Farshad M, Curt A. The Restless Spinal Cord in Degenerative Cervical Myelopathy.  AJNR Am J Neuroradiol. 2021 Mar;42(3):597-609. doi: 10.3174/ajnr.A6958. Epub 2021 Feb 4. PMID: 33541903    PubMed

Sanne Kikkert, Dario Pfyffer, Michaela Verling, Patrick Freund, Nicole Wenderoth. Finger somatotopy is preserved after tetraplegia but deteriorates over time. bioRxiv  2021.02.08.430185;  doi: https://doi.org/10.1101/2021.02.08.430185     bioRxiv

Pfyffer D, Vallotton K, Curt A, Freund P. Predictive Value of Midsagittal Tissue Bridges on Functional Recovery After Spinal Cord Injury. Neurorehabil Neural Repair. 2021;35(1):33-43. doi:10.1177/1545968320971787.    PubMed

Azzarito M, Kyathanahally SP, Balbastre Y, Seif M, Blaiotta C, Callaghan MF, Ashburner J, Freund P. Simultaneous voxel-wise analysis of brain and spinal cord morphometry and microstructure within the SPM framework. Hum Brain Mapp. 2021 Jan;42(1):220-232. doi: 10.1002/hbm.25218.    PubMed

 
 

2020

Pfyffer D, Vallotton K, Curt A, Freund P. Tissue bridges predict neuropathic pain emergence after spinal cord injury. J Neurol Neurosurg Psychiatry. 2020;91(10):1111-1117. doi:10.1136/jnnp-2020-323150.      PubMed

Leutritz T, Seif M, Helms G, Samson RS, Curt A, Freund P, Weiskopf N. Multiparameter mapping of relaxation (R1, R2*), proton density and magnetization transfer saturation at 3 T: A multicenter dual-vendor reproducibility and repeatability study. Hum Brain Mapp. 2020 Oct 15;41(15):4232-4247. doi: 10.1002/hbm.25122.    PubMed

Huber E, Patel R, Hupp M, Weiskopf N, Chakravarty MM, Freund P. Extrapyramidal plasticity predicts recovery after spinal cord injury. Sci Rep. 2020 Aug 24;10(1):14102. doi: 10.1038/s41598-020-70805-5. 

PubMed

Pfyffer D, Wyss PO, Huber E, Curt A, Henning A, Freund P. Metabolites of neuroinflammation relate to neuropathic pain after spinal cord injury. Neurology. 2020;95(7):e805-e814. doi:10.1212/WNL.0000000000010003.     PubMed

Birkhäuser V, Liechti MD, Anderson CE, Bachmann LM, Baumann S, Baumberger M, Birder LA, Botter SM, Büeler S, Cruz CD, David G, Freund P, Friedl S, Gross O, Hund-Georgiadis M, Husmann K, Jordan X, Koschorke M, Leitner L, Luca E, Mehnert U, Möhr S, Mohammadzada F, Monastyrskaya K, Pfender N, Pohl D, Sadri H, Sartori AM, Schubert M, Sprengel K, Stalder SA, Stoyanov J, Stress C, Tatu A, Tawadros C, van der Lely S, Wöllner J, Zubler V, Curt A, Pannek J, Brinkhof MWG, Kessler TM. TASCI-transcutaneous tibial nerve stimulation in patients with acute spinal cord injury to prevent neurogenic detrusor overactivity: protocol for a nationwide, randomised, sham-controlled, double-blind clinical trial. BMJ Open. 2020 Aug 13;10(8):e039164. doi: 10.1136/bmjopen-2020-039164.    PubMed

Curt A, Hsieh J, Schubert M, Hupp M, Friedl S, Freund P, Huber E, Pfyffer D, Sutter R, Jutzeler C, Wüthrich RP, Min K, Casha S, Fehlings MG, Guzman R. The Damaged Spinal Cord Is a Suitable Target for Stem Cell Transplantation. Neurorehabil Neural Repair. 2020 Aug;34(8):758-768. doi: 10.1177/1545968320935815.  PubMed

Seif M, David G, Huber E, Vallotton K, Curt A, Freund P. Cervical Cord Neurodegeneration in Traumatic and Non-Traumatic Spinal Cord Injury. J Neurotrauma. 2020 Mar 15;37(6):860-867. doi: 10.1089/neu.2019.6694.  PubMed

Azzarito M, Seif M, Kyathanahally S, Curt A, Freund P. Tracking the neurodegenerative gradient after spinal cord injury. Neuroimage Clin. 2020;26:102221. doi: 10.1016/j.nicl.2020.102221.    PubMed

2019

Freund P, Seif M, Weiskopf N, Friston K, Fehlings MG, Thompson AJ, Curt A. MRI in traumatic spinal cord injury: from clinical assessment to neuroimaging biomarkers. Lancet Neurol. 2019 Dec;18(12):1123-1135. doi: 10.1016/S1474-4422(19)30138-3. ​   PubMed

David G, Mohammadi S, Martin AR, et al. Traumatic and nontraumatic spinal cord injury: pathological insights from neuroimaging. Nat Rev Neurol. 2019;15:718–731.    PubMed

Pfyffer D, Huber E, Sutter R, Curt A, Freund P. Tissue bridges predict recovery after traumatic and ischemic thoracic spinal cord injury. Neurology. 2019;93(16):e1550-e1560. doi:10.1212/WNL.0000000000008318.

PubMed

Seif M, Gandini Wheeler-Kingshott CA, Cohen-Adad J, Flanders AE, Freund P. Guidelines for the conduct of clinical trials in spinal cord injury: Neuroimaging biomarkers. Spinal Cord. 2019 Sep;57(9):717-728. doi: 10.1038/s41393-019-0309-x.    PubMed

Vallotton K, Huber E, Sutter R, Curt A, Hupp M, Freund P. Width and neurophysiologic properties of tissue bridges predict recovery after cervical injury. Neurology. 2019 Jun 11;92(24):e2793-e2802. doi: 10.1212/WNL.0000000000007642.    PubMed

Wyss PO, Huber E, Curt A, Kollias S, Freund P, Henning A. MR Spectroscopy of the Cervical Spinal Cord in Chronic Spinal Cord Injury. Radiology. 2019 Apr;291(1):131-138. doi: 10.1148/radiol.2018181037.    PubMed

David G, Seif M, Huber E, et al. In vivo evidence of remote neural degeneration in the lumbar enlargement after cervical injury. Neurology. 2019;92.     PubMed

2018

Seif M, Ziegler G, Freund P. Progressive Ventricles Enlargement and Cerebrospinal Fluid Volume Increases as a Marker of Neurodegeneration in Patients with Spinal Cord Injury: A Longitudinal Magnetic Resonance Imaging Study. J Neurotrauma. 2018 Dec 15;35(24):2941-2946. doi: 10.1089/neu.2017.5522.    PubMed

Seif M, Curt A, Thompson AJ, Grabher P, Weiskopf N, Freund P. Quantitative MRI of rostral spinal cord and brain regions is predictive of functional recovery in acute spinal cord injury. Neuroimage Clin. 2018 Aug 19;20:556-563. doi: 10.1016/j.nicl.2018.08.026.​    PubMed

Wolf K, Hupp M, Friedl S, Sutter R, Klarhöfer M, Grabher P, Freund P, Curt A. In cervical spondylotic myelopathy spinal cord motion is focally increased at the level of stenosis: a controlled cross-sectional study. Spinal Cord. 2018 Aug;56(8):769-776. doi: 10.1038/s41393-018-0075-1. ​    PubMed

Huber E, David G, Thompson AJ, Weiskopf N, Mohammadi S, Freund P. Dorsal and ventral horn atrophy is associated with clinical outcome after spinal cord injury. Neurology. 2018 Apr 24;90(17):e1510-e1522. doi: 10.1212/WNL.0000000000005361.     PubMed

Ziegler G, Grabher P, Thompson A, Altmann D, Hupp M, Ashburner J, Friston K, Weiskopf N, Curt A, Freund P. Progressive neurodegeneration following spinal cord injury: Implications for clinical trials. Neurology. 2018 Apr 3;90(14):e1257-e1266. doi: 10.1212/WNL.0000000000005258.    PubMed

2017

2016

David G, Freund P, Mohammadi S. The efficiency of retrospective artifact correction methods in improving the statistical power of between-group differences in spinal cord DTI. Neuroimage. 2017 Sep;158:296-307. doi: 10.1016/j.neuroimage.2017.06.051.    PubMed

Grabher P, Mohammadi S, David G, Freund P. Neurodegeneration in the Spinal Ventral Horn Prior to Motor Impairment in Cervical Spondylotic Myelopathy. J Neurotrauma. 2017 Aug 1;34(15):2329-2334. doi: 10.1089/neu.2017.4980.    PubMed

Grabher P, Blaiotta C, Ashburner J, Freund P. Relationship between brainstem neurodegeneration and clinical impairment in traumatic spinal cord injury. Neuroimage Clin. 2017 Jun 1;15:494-501. doi: 10.1016/j.nicl.2017.05.026.    PubMed

Huber E, Lachappelle P, Sutter R, Curt A, Freund P. Are midsagittal tissue bridges predictive of outcome after cervical spinal cord injury? Ann Neurol. 2017 May;81(5):740-748. doi: 10.1002/ana.24932.    PubMed

Prados F, Ashburner J, Blaiotta C, Brosch T, Carballido-Gamio J, Cardoso MJ, Conrad BN, Datta E, Dávid G, Leener B, Dupont SM, Freund P, Wheeler-Kingshott CAMG, Grussu F, Henry R, Landman BA, Ljungberg E, Lyttle B, Ourselin S, Papinutto N, Saporito S, Schlaeger R, Smith SA, Summers P, Tam R, Yiannakas MC, Zhu A, Cohen-Adad J. Spinal cord grey matter segmentation challenge. Neuroimage. 2017 May 15;152:312-329. doi: 10.1016/j.neuroimage.2017.03.010.   PubMed

Freund P, Friston K, Thompson AJ, Stephan KE, Ashburner J, Bach DR, Nagy Z, Helms G, Draganski B, Mohammadi S, Schwab ME, Curt A, Weiskopf N. Embodied neurology: an integrative framework for neurological disorders. Brain. 2016 Jun;139(Pt 6):1855-61. doi: 10.1093/brain/aww076.    PubMed

Grabher P, Mohammadi S, Trachsler A, Friedl S, David G, Sutter R, Weiskopf N, Thompson AJ, Curt A, Freund P. Voxel-based analysis of grey and white matter degeneration in cervical spondylotic myelopathy. Sci Rep. 2016 Apr 20;6:24636. doi: 10.1038/srep24636.     PubMed

Jutzeler CR, Huber E, Callaghan MF, Luechinger R, Curt A, Kramer JL, Freund P. Association of pain and CNS structural changes after spinal cord injury. Sci Rep. 2016 Jan 6;6:18534. doi: 10.1038/srep18534.    PubMed

2015

Jutzeler CR, Freund P, Huber E, Curt A, Kramer JLK. Neuropathic Pain and Functional Reorganization in the Primary Sensorimotor Cortex After Spinal Cord Injury. J Pain. 2015 Dec;16(12):1256-1267. doi: 10.1016/j.jpain.2015.08.008.​    PubMed

Grabher P, Callaghan MF, Ashburner J, Weiskopf N, Thompson AJ, Curt A, Freund P. Tracking sensory system atrophy and outcome prediction in spinal cord injury. Ann Neurol. 2015 Nov;78(5):751-61. doi: 10.1002/ana.24508. ​    PubMed

Huber E, Curt A, Freund P. Tracking trauma-induced structural and functional changes above the level of spinal cord injury. Curr Opin Neurol. 2015 Aug;28(4):365-72. doi: 10.1097/WCO.0000000000000224.  PubMed

Villiger M, Grabher P, Hepp-Reymond MC, Kiper D, Curt A, Bolliger M, Hotz-Boendermaker S, Kollias S, Eng K, Freund P. Relationship between structural brainstem and brain plasticity and lower-limb training in spinal cord injury: a longitudinal pilot study. Front Hum Neurosci. 2015 May 6;9:254. doi: 10.3389/fnhum.2015.00254.    PubMed

2013

Freund P, Weiskopf N, Ashburner J, Wolf K, Sutter R, Altmann DR, Friston K, Thompson A, Curt A. MRI investigation of the sensorimotor cortex and the corticospinal tract after acute spinal cord injury: a prospective longitudinal study. Lancet Neurol. 2013 Sep;12(9):873-881. doi: 10.1016/S1474-4422(13)70146-7.​

PubMed

Freund P, Curt A, Friston K, Thompson A. Tracking changes following spinal cord injury: insights from neuroimaging. Neuroscientist. 2013 Apr;19(2):116-28. doi: 10.1177/1073858412449192.     PubMed